Recently Miguel announced MonoMac, a new Mono binding for Cocoa & other Objective-C libraries, based on the MonoTouch binding generator and Objective-C bridge.
This is exciting for many people because it allows writing native Mac GUIs using C# and other .NET languages. I have put together a MonoDevelop addin that simplifies the process of creating, developing and debugging a MonoMac application.
[UPDATE]: It has been pointed out to me that the premise of this article is wrong. The compiler specifically avoids this problem by hoisting the captured variables into an inner class of which the generated method is also an instance member, and creating a new instance of this class for each call.
The inbound (Mono -> Gecko) C++ DOM function is working fine and I can recieve a C# call in JavaScript; now I just need to pass it off to the actual function.
There was a bit of trouble initially as I couldn't obtain an nsIWebBrowser pointer from gtk_moz_embed_get_nsIWebBrowser. This turned out to be because the Gecko# WebControl hadn't been shown yet (i.e. window.ShowAll()), but I didn't figure this out as other functions like gtk_moz_embed_get_location worked fine.
Implementing the ASP.NET GUI designer with Mozilla's Gecko web rendering engine is an obvious decision: it's open-source, has strong standards support and a large feature set, is highly extensible and flexible thanks to its XPCOM component system, and using Gecko# it can be embedded in a GTK# GUI. Mozilla is becoming an application platform, with XUL for declaratively writting GUIs, and JavaScript for program logic.
Gecko# wraps GtkMozEmbed, which is a C GTK widget, hiding Mozilla's native C++. Understandably this widget isn't bloated by wrapping the Mozilla DOM or other internals: it claims to exposes enough functionality for "about 80% of uses". Essentially this means a basic web browser.